Primary Identifier | MGI:2182928 | Organism | mouse, laboratory |
Chromosome | 17 | NCBI Gene Number | 224792 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable G protein-coupled receptor activity. Involved in surfactant homeostasis. Acts upstream of or within several processes, including glomerular filtration; negative regulation of macrophage activation; and pharyngeal arch artery morphogenesis. Located in apical part of cell. Is expressed in several structures, including cardiovascular system; genitourinary system; gut; hemolymphoid system; and respiratory system. Orthologous to human ADGRF5 (adhesion G protein-coupled receptor F5). PHENOTYPE: Mice homozygous for a knock-out allele exhibit premature death, decreased body weight and respiratory distress associated with pulmonary alveolar proteinosis. [provided by MGI curators] |