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Protein Coding Gene : Mep1a meprin 1 alpha
Primary Identifier  MGI:96963 Organism  mouse, laboratory
Chromosome  17 NCBI Gene Number  17287
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0)

Predicted to enable metallodipeptidase activity and metalloendopeptidase activity. Predicted to be involved in epidermal growth factor receptor ligand maturation. Located in membrane. Is expressed in several structures, including gut and metanephros. Orthologous to human MEP1A (meprin A subunit alpha).
PHENOTYPE: Mice homozygous for a knock-out allele exhibit decreased litter size, reduced LPS-induced renal injury and bladder inflammation, and increased susceptibility to sodium dextran sulfate-induced colitis. [provided by MGI curators]
  • synonyms:
  • meprin 1 alpha,
  • expressed sequence AI098089,
  • meprin 1,
  • Mep-1a,
  • MGD-MRK-12196,
  • Mep1,
  • expressed sequence AW107200,
  • meprin alpha,
  • AI098089,
  • MGD-MRK-12193,
  • Mep1a,
  • MGD-MRK-12194,
  • MGD-MRK-12197,
  • AW107200,
  • meprin A alpha-subunit,
  • MGI:2147044,
  • Mep-1,
  • MGI:2146793
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