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Protein Coding Gene : Aars2 alanyl-tRNA synthetase 2, mitochondrial
Primary Identifier  MGI:2681839 Organism  mouse, laboratory
Chromosome  17 NCBI Gene Number  224805
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0)

Enables peptide lactyltransferase (ATP-dependent) activity. Involved in negative regulation of cGAS/STING signaling pathway. Located in mitochondrion. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 8 and progressive leukoencephalopathy with ovarian failure. Orthologous to human AARS2 (alanyl-tRNA synthetase 2, mitochondrial).
PHENOTYPE: Alleles with single amino acid substitutions that result in loss of tRNA proofreading are embryonic lethal and E8.5 embryos are small. [provided by MGI curators]
  • synonyms:
  • Aars2,
  • alanyl-tRNA synthetase like,
  • MGC:69820,
  • MGI:2684935,
  • Gm89,
  • Aarsl,
  • gene model 89, (NCBI),
  • alanyl-tRNA synthetase 2, mitochondrial
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