| Primary Identifier | MGI:1913765 | Organism | mouse, laboratory |
| Chromosome | 17 | NCBI Gene Number | 66515 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable ubiquitin protein ligase binding activity. Involved in vasculogenesis. Part of Cul7-RING ubiquitin ligase complex. Is expressed in several structures, including Meckel's cartilage; extraembryonic component; placenta; and skeleton. Human ortholog(s) of this gene implicated in 3-M syndrome. Orthologous to human CUL7 (cullin 7). PHENOTYPE: During late gestation, homozygous null fetuses display reduced growth associated with abnormal placental development and hemorrhaging due to vascular defects. Mutant mice are born but die shortly after birth, succumbing to respiratory distress. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
