| Primary Identifier | MGI:107687 | Organism | mouse, laboratory |
| Chromosome | 17 | NCBI Gene Number | 17240 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables DNA-binding transcription factor binding activity. Involved in dorsal/ventral axis specification; negative regulation of transcription by RNA polymerase II; and regulation of signal transduction. Acts upstream of or within embryonic skeletal system morphogenesis and trophoblast giant cell differentiation. Located in nucleus. Is expressed in several structures, including medulla oblongata basal plate mantle layer; notochord; sensory organ; skeleton; and trophectoderm. Orthologous to human MDFI (MyoD family inhibitor). PHENOTYPE: Homozygotes for a targeted null mutation on a C57BL/6 background exhibit a placental defect and die around embryonic day 10.5, but on a 129/Sv background, mutants survive to adulthood and show delayed caudal neural tube closure and skeletal abnormalities. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
