Primary Identifier | MGI:1918576 | Organism | mouse, laboratory |
Chromosome | 17 | NCBI Gene Number | 71326 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable transmembrane signaling receptor activity. Involved in platelet activation. Located in cell surface and platelet alpha granule. Is expressed in liver lobe and testis. Orthologous to human TREML1 (triggering receptor expressed on myeloid cells like 1). PHENOTYPE: Mice homozygous for a knock-out allele show a reduced platelet count, defective platelet aggregation, prolonged bleeding times, enhanced inflammatory hemorrhage, and increased susceptibility to death from endotoxin (LPS) challenge. [provided by MGI curators] |