| Primary Identifier | MGI:1354171 | Organism | mouse, laboratory |
| Chromosome | 17 | NCBI Gene Number | 50498 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables interleukin-27 receptor binding activity. Involved in T cell proliferation. Predicted to be located in extracellular space and membrane. Is expressed in several structures, including decidua; extraembryonic component; sensory organ; and skeleton. Orthologous to human EBI3 (Epstein-Barr virus induced 3). PHENOTYPE: Mice homozygous for a knock-out allele exhibit significantly reduced numbers of invariant natural killer (NK) T cells, show impaired Th2 responses, are resistant to the induction of oxazolone-induced colitis, and display impaired early Th1 immunity against Leishmania parasitic infections. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
