Primary Identifier | MGI:1351331 | Organism | mouse, laboratory |
Chromosome | 17 | NCBI Gene Number | 27221 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable chromo shadow domain binding activity and identical protein binding activity. Predicted to be involved in DNA replication-dependent chromatin assembly and nucleosome assembly. Predicted to be located in chromatin. Predicted to be part of CAF-1 complex. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in colon cancer; high grade glioma; neuroblastoma; and systemic lupus erythematosus. Orthologous to human CHAF1A (chromatin assembly factor 1 subunit A). PHENOTYPE: Mice homozygous for a null mutation in this gene display lethality before implantation, embryonic growth arrest, and abnormal heterochromatin morphology. [provided by MGI curators] |