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Protein Coding Gene : Lrg1 leucine-rich alpha-2-glycoprotein 1
Primary Identifier  MGI:1924155 Organism  mouse, laboratory
Chromosome  17 NCBI Gene Number  76905
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0)

Enables transforming growth factor beta receptor binding activity. Acts upstream of or within several processes, including brown fat cell differentiation; positive regulation of endothelial cell proliferation; and positive regulation of transforming growth factor beta receptor signaling pathway. Located in extracellular space. Is expressed in pancreas mesenchyme. Orthologous to human LRG1 (leucine rich alpha-2-glycoprotein 1).
PHENOTYPE: Mice homozygous for a knock-out allele exhibit Tgfbr1-dependent increased growth of LCC tumor allografts. [provided by MGI curators]
  • synonyms:
  • RIKEN cDNA 2310031E04 gene,
  • RIKEN cDNA 1300008B03 gene,
  • Lrhg,
  • 1300008B03Rik,
  • 2310031E04Rik,
  • leucine-rich alpha-2-glycoprotein 1,
  • MGI:1916869,
  • Lrg1
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