Primary Identifier | MGI:2443967 | Organism | mouse, laboratory |
Chromosome | 17 | NCBI Gene Number | 224897 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable dipeptidyl-peptidase activity and identical protein binding activity. Predicted to be involved in negative regulation of programmed cell death and proteolysis. Predicted to act upstream of with a negative effect on pyroptotic inflammatory response. Predicted to be located in cell leading edge and microtubule. Predicted to be active in cytosol. Is expressed in several structures, including forelimb bud; gut; male reproductive gland or organ; myotome; and nervous system. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human DPP9 (dipeptidyl peptidase 9). PHENOTYPE: Homozygous mutants display partial neonatal lethality and complete lethality at preweaning stages with defects suckling due to undeveveloped tongue muscle. [provided by MGI curators] |