| Primary Identifier | MGI:1338889 | Organism | mouse, laboratory |
| Chromosome | 17 | NCBI Gene Number | 18140 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables several functions, including hemi-methylated DNA-binding activity; histone H3 ubiquitin ligase activity; and identical protein binding activity. Involved in negative regulation of gene expression via chromosomal CpG island methylation and negative regulation of transcription by RNA polymerase II. Located in heterochromatin; nuclear matrix; and replication fork. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; hindlimb phalanx; and sensory organ. Orthologous to human UHRF1 (ubiquitin like with PHD and ring finger domains 1). PHENOTYPE: Mice homozygous for disruption of this marker die early in gestation showing growth retardation and various malformations. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
