Primary Identifier | MGI:2670904 | Organism | mouse, laboratory |
Chromosome | 17 | NCBI Gene Number | 224912 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable SH3 domain binding activity. Involved in positive regulation of cell junction assembly. Located in apical part of cell. Part of subapical complex. Is expressed in several structures, including central nervous system; early conceptus; and retina. Orthologous to human CRB3 (crumbs cell polarity complex component 3). PHENOTYPE: Mice homozygous for a knock-out allele exhibit neonatal lethality likely due to respiratory distress, abnormal pulmonary alveolus morphology, kidney cysts and abnormal small intestinal morphology. [provided by MGI curators] |