| Primary Identifier | MGI:107444 | Organism | mouse, laboratory |
| Chromosome | 17 | NCBI Gene Number | 13640 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables chemorepellent activity; ephrin receptor binding activity; and neurotrophin TRKB receptor binding activity. Involved in several processes, including ephrin receptor signaling pathway; positive regulation of nervous system development; and synaptic membrane adhesion. Acts upstream of or within cellular response to follicle-stimulating hormone stimulus; cellular response to forskolin; and retinal ganglion cell axon guidance. Located in adherens junction; basement membrane; and plasma membrane. Is active in GABA-ergic synapse. Is expressed in several structures, including alimentary system; embryo ectoderm; limb; nervous system; and sensory organ. Used to study anencephaly. Orthologous to human EFNA5 (ephrin A5). PHENOTYPE: Nullizygous mice show defects in establishing axonal connections involving retinal, motor, vomeronasal and tactile axons to their respective targets. Some mice develop neural tube defects. Females show subfertility, impaired response to hCG, follicle rupture defects, and reduced ovulatory capacity. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
