| Primary Identifier | MGI:108466 | Organism | mouse, laboratory |
| Chromosome | 17 | NCBI Gene Number | 19765 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables GTPase activator activity and small GTPase binding activity. Involved in positive regulation of GTPase activity. Predicted to be located in mitochondrion; nuclear body; and plasma membrane. Predicted to be active in Schaffer collateral - CA1 synapse and membrane. Used to study microphthalmia. Human ortholog(s) of this gene implicated in pancreatic adenocarcinoma. Orthologous to human RALBP1 (ralA binding protein 1). PHENOTYPE: Homozygous and heterozygous null mice display increased sensitivity to X-ray irradiation, increased oxidative stress, and impaired glutathione homeostasis. Mice homozygous for a gene trap insertion exhibit decreases in exploratory and locomotor activity and a decreased sensitivity to pain. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
