Primary Identifier | MGI:1914302 | Organism | mouse, laboratory |
Chromosome | 17 | NCBI Gene Number | 67052 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables cyclin binding activity. Acts upstream of or within several processes, including kinetochore organization; meiosis I cell cycle process; and skeletal muscle satellite cell proliferation. Located in centrosome; cytoplasm; and kinetochore. Orthologous to human NDC80 (NDC80 kinetochore complex component). PHENOTYPE: Mice homozygous for a knock-out allele show complete embryonic lethality prior to organogenesis. In vitro, blastocysts fail to hatch from the zona pellucida and die after 3 days in culture. [provided by MGI curators] |