| Primary Identifier | MGI:2150380 | Organism | mouse, laboratory |
| Chromosome | 17 | NCBI Gene Number | 94224 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables 3-oxo-5-alpha-steroid 4-dehydrogenase activity. Involved in androgen biosynthetic process. Acts upstream of or within male genitalia development and steroid biosynthetic process. Predicted to be located in cell body fiber and neuronal cell body. Predicted to be active in endoplasmic reticulum membrane. Is expressed in genitourinary system. Human ortholog(s) of this gene implicated in hypospadias and prostate cancer. Orthologous to human SRD5A2 (steroid 5 alpha-reductase 2). PHENOTYPE: Homozygous null mutant males are fertile, but have small prostates and seminal vesicles, elevated testosterone in reproductive tissue and decreased androgen-dependent gene expression. Mutant females exhibit no detectable abnormality. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
