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Protein Coding Gene : Ttc7 tetratricopeptide repeat domain 7
Primary Identifier  MGI:1920999 Organism  mouse, laboratory
Chromosome  17 NCBI Gene Number  225049
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0)

Acts upstream of or within hemopoiesis and intracellular iron ion homeostasis. Predicted to be located in cytoplasm. Predicted to be active in plasma membrane. Used to study psoriasis. Human ortholog(s) of this gene implicated in multiple intestinal atresia. Orthologous to human TTC7A (tetratricopeptide repeat domain 7A).
PHENOTYPE: Homozygotes for a spontaneous mutation exhibit reduced growth, sparse hair, thickened, scaly skin, increased numbers of splenic B cells, macrophages, and erythroid cells, elevated IgE, glomerulonephritis, and forestomach papillomas. [provided by MGI curators]
  • synonyms:
  • Ttc7,
  • MGI:1922718,
  • 1700007L07Rik,
  • MGI:96068,
  • MGD-MRK-9877,
  • hereditary erythroblastic anemia,
  • MGI:95584,
  • hea,
  • MGD-MRK-10690,
  • RIKEN cDNA 1700007L07 gene,
  • tetratricopeptide repeat domain 7,
  • 1110035E02Rik,
  • flaky skin,
  • RIKEN cDNA 1110035E02 gene,
  • fsn
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