| Primary Identifier | MGI:88495 | Organism | mouse, laboratory |
| Chromosome | 18 | NCBI Gene Number | 12916 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in circadian regulation of gene expression; negative regulation of DNA-templated transcription; and response to cAMP. Acts upstream of or within glycosphingolipid metabolic process; positive regulation of transcription by RNA polymerase II; and spermatogenesis. Located in cytoplasm and nucleus. Part of transcription regulator complex. Is expressed in several structures, including liver; lung; palatal shelf; testis; and ureter. Orthologous to human CREM (cAMP responsive element modulator). PHENOTYPE: Homozygotes for targeted mutations exhibit reduced regenerative capacity after partial hepatectomy and reduced cardiac function. Males are sterile due to a block in spermiogenesis associated with a lack of postmeiotic gene expression. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
