Primary Identifier | MGI:1919668 | Organism | mouse, laboratory |
Chromosome | 18 | NCBI Gene Number | 225160 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable DNA binding activity and RNA binding activity. Predicted to be involved in mRNA export from nucleus. Predicted to act upstream of or within apoptotic process and regulation of apoptotic process. Predicted to be located in cytoplasm and nuclear speck. Predicted to be part of THO complex part of transcription export complex. Predicted to colocalize with chromosome, telomeric region. Is expressed in early conceptus and embryo. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 86. Orthologous to human THOC1 (THO complex subunit 1). PHENOTYPE: Mutations in this gene result in embryonic lethality around implantation in homozygotes. [provided by MGI curators] |