| Primary Identifier | MGI:3576497 | Organism | mouse, laboratory |
| Chromosome | 18 | NCBI Gene Number | 381157 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Acts upstream of or within several processes, including kidney development; paramesonephric duct development; and reproductive structure development. Predicted to be located in membrane. Is expressed in several structures, including brain; liver; tail unsegmented mesenchyme; thymus; and urinary system. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 80 and renal agenesis. Orthologous to human GREB1L (GREB1 like retinoic acid receptor coactivator). PHENOTYPE: Mice homozygous for a knock-out allele exhibit embryonic lethality, decreased embryo size, bilateral kidney agenesis, absence of Wolffian and Mullerian ducts, small testis, heart defects, and exencephaly. Heterozygotes display a slight decrease in ureteric bud branching morphogenesis. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
