| Primary Identifier | MGI:2152345 | Organism | mouse, laboratory |
| Chromosome | 18 | NCBI Gene Number | 72504 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable DNA binding activity and NF-kappaB binding activity. Predicted to contribute to RNA polymerase II general transcription initiation factor activity. Involved in positive regulation of stem cell proliferation. Predicted to be located in fibrillar center and nucleoplasm. Predicted to be part of transcription factor TFIID complex. Is expressed in genitourinary system and tail. Human ortholog(s) of this gene implicated in spermatogenic failure 13. Orthologous to human TAF4B (TATA-box binding protein associated factor 4b). PHENOTYPE: Homozygous null male mice are initially fertile but show progressive germ cell loss, seminiferous tubule degeneration and spermatogonia defects leading to sterility. Females are sterile and show premature ovarian aging, persistent estrous, elevated FSH levels and reduced primordial follicle numbers. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
