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Protein Coding Gene : Dsg3 desmoglein 3
Primary Identifier  MGI:99499 Organism  mouse, laboratory
Chromosome  18 NCBI Gene Number  13512
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0)

Enables protein dimerization activity. Involved in desmosome assembly; negative regulation of cell migration; and negative regulation of p38MAPK cascade. Located in plasma membrane. Is expressed in several structures, including epithelium and skin. Used to study pemphigus vulgaris. Orthologous to human DSG3 (desmoglein 3).
PHENOTYPE: Homozygous mutants display runting from decreased food intake due to oropharyngeal epithelial lesions, blisters around snout and eyes, hair loss by weaning, and hair regrowth with bald patches throughout life. [provided by MGI curators]
  • synonyms:
  • Dsg3,
  • bal,
  • MGD-MRK-16273,
  • MGD-MRK-1495,
  • MGI:88129,
  • desmoglein 3,
  • balding
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Features --> Cross References

Genome

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0 Exons

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0 Involved In Mutations

0 Strain

0 Transcripts

1 Transgenic Expressors

0 UTRs

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

Gene --> Proteins

Function

Mouse features --> Functions (GO terms)

Homology

Genes --> Homologs

Interactions

8 Pathways

0 Targeted By

Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

Literature

Mouse features --> Publications

 

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