Primary Identifier | MGI:96964 | Organism | mouse, laboratory |
Chromosome | 18 | NCBI Gene Number | 17288 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable identical protein binding activity and metalloendopeptidase activity. Predicted to be involved in inflammatory response and proteolysis. Located in membrane. Is expressed in cortical early distal tubule; cortical early proximal tubule; intestine; intestine epithelium; and metanephros. Orthologous to human MEP1B (meprin A subunit beta). PHENOTYPE: Homozygotes for a targeted null mutation exhibit 50% prenatal lethality; survivors have reduced birth weight and show altered renal gene expression, but otherwise are apparently normal. [provided by MGI curators] |