Primary Identifier | MGI:1932407 | Organism | mouse, laboratory |
Chromosome | 18 | NCBI Gene Number | 108013 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables mRNA binding activity. Acts upstream of or within several processes, including mRNA splice site recognition; negative regulation of excitatory postsynaptic potential; and negative regulation of mRNA splicing, via spliceosome. Located in cytoplasm and nucleus. Is expressed in several structures, including central nervous system; embryo ectoderm; gonad; mammary gland; and retina. Orthologous to human CELF4 (CUGBP Elav-like family member 4). PHENOTYPE: Mice homozygous for a null allele exhibit neonatal lethality, shortened life span dependent on genetic background, and seizures. Mice heterozygous for a null allele exhibit complex seizures and abnormal body weights depending on age. [provided by MGI curators] |