Primary Identifier | MGI:101759 | Organism | mouse, laboratory |
Chromosome | 18 | NCBI Gene Number | 20983 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables calcium ion binding activity and calcium-dependent phospholipid binding activity. Involved in several processes, including regulation of secretion by cell; regulation of trans-synaptic signaling; and regulation of vesicle-mediated transport. Acts upstream of or within neurotransmitter secretion. Located in several cellular components, including astrocyte projection; dense core granule; and microvesicle. Is active in glutamatergic synapse and neuronal dense core vesicle membrane. Is expressed in several structures, including alimentary system; limb; nervous system; respiratory system; and sensory organ. Orthologous to human SYT4 (synaptotagmin 4). PHENOTYPE: Homozygotes for a targeted null mutation exhibit impairments in motor coordination, contextual fear conditioning, and social transmission of food preference. [provided by MGI curators] |