| Primary Identifier | MGI:2389174 | Organism | mouse, laboratory |
| Chromosome | 18 | NCBI Gene Number | 107065 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable neurexin family protein binding activity. Acts upstream of or within several processes, including long-term synaptic potentiation; negative regulation of receptor internalization; and positive regulation of synapse assembly. Predicted to be located in excitatory synapse and membrane. Predicted to be active in several cellular components, including Schaffer collateral - CA1 synapse; hippocampal mossy fiber to CA3 synapse; and postsynaptic density membrane. Is expressed in neural tube and neural tube lateral wall. Orthologous to human LRRTM2 (leucine rich repeat transmembrane neuronal 2). PHENOTYPE: When conditionally deleted in addition to Lrrtm1, mice homozygous for a conditional allele exhibit impaired basal AMPA receptor transmission and LTP. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
