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Protein Coding Gene : Sil1 SIL1 nucleotide exchange factor
Primary Identifier  MGI:1932040 Organism  mouse, laboratory
Chromosome  18 NCBI Gene Number  81500
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0)

Predicted to enable adenyl-nucleotide exchange factor activity and identical protein binding activity. Predicted to be involved in protein transport. Located in endoplasmic reticulum. Is expressed in brain; chondrocranium; eye; pancreas; and testis. Human ortholog(s) of this gene implicated in primary cerebellar degeneration. Orthologous to human SIL1 (SIL1 nucleotide exchange factor).
PHENOTYPE: Mice homozygous for a gene trapped allele or spontaneous mutation exhibit ataxia and Purkinje cell degeneration. [provided by MGI curators]
  • synonyms:
  • 1810057E01Rik,
  • expressed sequence AI042831,
  • SIL1 nucleotide exchange factor,
  • RIKEN cDNA 1810057E01 gene,
  • woozy,
  • MGI:2147193,
  • MGI:2182806,
  • AI042831,
  • Sil1,
  • MGI:1923775,
  • wz
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