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Protein Coding Gene : Prdm6 PR domain containing 6
Primary Identifier  MGI:2684938 Organism  mouse, laboratory
Chromosome  18 NCBI Gene Number  225518
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0)

Enables identical protein binding activity. Acts upstream of or within negative regulation of DNA-templated transcription; negative regulation of smooth muscle cell differentiation; and neurogenesis. Located in nucleus. Is expressed in several structures, including arterial system; extraembryonic component; genitourinary system; immune system; and trunk mesenchyme. Human ortholog(s) of this gene implicated in patent ductus arteriosus. Orthologous to human PRDM6 (PR/SET domain 6).
PHENOTYPE: Mice homozygous for a knock-out allele exhibit cardiovascular development defects. [provided by MGI curators]
  • synonyms:
  • gene model 92, (NCBI),
  • Gm92,
  • LOC225518,
  • PR domain containing 6,
  • PRISM,
  • Prdm6
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