| Primary Identifier | MGI:1926259 | Organism | mouse, laboratory |
| Chromosome | 18 | NCBI Gene Number | 60440 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables GTPase activity; guanyl ribonucleotide binding activity; and identical protein binding activity. Involved in defense response to Gram-negative bacterium; defense response to protozoan; and regulation of autophagy. Acts upstream of or within cellular response to interferon-beta and response to bacterium. Located in endoplasmic reticulum membrane and symbiont-containing vacuole membrane. Is active in cytoplasm. Is expressed in several structures, including foregut; genitourinary system; heart; limb; and respiratory system. PHENOTYPE: Targeted deletion of this gene results in partial loss of IFN-gamma-mediated Toxoplasma gondii growth restriction in primary mouse astrocytes. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
