| Primary Identifier | MGI:2444934 | Organism | mouse, laboratory |
| Chromosome | 18 | NCBI Gene Number | 170826 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable AF-2 domain binding activity; nuclear estrogen receptor binding activity; and nuclear receptor coactivator activity. Involved in several processes, including bone trabecula formation; positive regulation of bone resorption; and positive regulation of metabolic process. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of mediator complex. Predicted to be active in nucleus. Is expressed in brown fat; central nervous system; heart; sensory organ; and tibialis anterior. Human ortholog(s) of this gene implicated in obesity. Orthologous to human PPARGC1B (PPARG coactivator 1 beta). PHENOTYPE: Homozygous inactivation of this gene can lead to postnatal lethality and impaired mitochondrial activity, adaptive thermogenesis, and hepatic function. Homozygotes for a null allele also display a defect in heart rate regulation, reduced body weight and WAT content, and increased energy expenditure. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
