| Primary Identifier | MGI:87938 | Organism | mouse, laboratory |
| Chromosome | 18 | NCBI Gene Number | 11555 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables adenylate cyclase binding activity and beta2-adrenergic receptor activity. Involved in cellular response to amyloid-beta; positive regulation of cold-induced thermogenesis; and positive regulation of signal transduction. Acts upstream of or within several processes, including bone resorption; brown fat cell differentiation; and diet induced thermogenesis. Located in apical plasma membrane and nucleus. Is active in neuronal dense core vesicle. Is expressed in several structures, including central nervous system; early conceptus; heart; liver; and sensory organ. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); disease of metabolism (multiple); kidney failure (multiple); lung disease (multiple); and open-angle glaucoma (multiple). Orthologous to human ADRB2 (adrenoceptor beta 2). PHENOTYPE: Mice homozygous for targeted mutations that inactivate the gene exhibit increased bone mass. The primary physiological consequences are seen during exercise stress and result from alterations in vascular tone and energy metabolism. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
