Primary Identifier | MGI:3644691 | Organism | mouse, laboratory |
Chromosome | 18 | NCBI Gene Number | 408198 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable serine-type endopeptidase inhibitor activity. Acts upstream of or within inflammatory response and negative regulation of cytokine production involved in inflammatory response. Located in extracellular space. Orthologous to human SPINK7 (serine peptidase inhibitor Kazal type 7). PHENOTYPE: Mcie homozygous for a null allele exhibit increased susceptibility to DSS-induced colitis. [provided by MGI curators] |