| Primary Identifier | MGI:1918781 | Organism | mouse, laboratory |
| Chromosome | 18 | NCBI Gene Number | 667742 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables mechanosensitive monoatomic ion channel activity and monoatomic cation channel activity. Involved in detection of mechanical stimulus involved in sensory perception and monoatomic cation transport. Acts upstream of or within regulation of membrane potential. Located in cuticular plate; neuronal cell body membrane; and stereocilium. Is expressed in dorsal root ganglion and lung. Human ortholog(s) of this gene implicated in distal arthrogryposis type 3 and distal arthrogryposis type 5. Orthologous to human PIEZO2 (piezo type mechanosensitive ion channel component 2). PHENOTYPE: Mice homozygous for a null allele exhibit impaired injury-induced tactile pain detection. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
