Primary Identifier | MGI:2676805 | Organism | mouse, laboratory |
Chromosome | 18 | NCBI Gene Number | 387231 |
Mgi Type | miRNA gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Acts upstream of or within several processes, including BMP signaling pathway; erythrocyte differentiation; and multicellular organismal-level iron ion homeostasis. Part of RISC complex. Is expressed in embryo; liver; and lung. Human ortholog(s) of this gene implicated in hepatocellular carcinoma. Orthologous to human MIR122 (microRNA 122). PHENOTYPE: Mice homozygous for a knock-out allele exhibit steatohepatitis with fibrosis and hepatocellular carcinoma. [provided by MGI curators] |