| Primary Identifier | MGI:1930146 | Organism | mouse, laboratory |
| Chromosome | 18 | NCBI Gene Number | 58801 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Involved in several processes, including apoptotic signaling pathway; negative regulation of mitochondrial membrane potential; and positive regulation of cysteine-type endopeptidase activity. Acts upstream of or within several processes, including intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; positive regulation of apoptotic process; and positive regulation of establishment of protein localization to mitochondrion. Located in mitochondrion. Is expressed in several structures, including brain; genitourinary system; immune system; limb; and liver. Orthologous to human PMAIP1 (phorbol-12-myristate-13-acetate-induced protein 1). PHENOTYPE: Though inactivation of this gene results in apoptotic abnormalities, homozygous null mice develop normally and show no evidence of tumorigenesis. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
