| Primary Identifier | MGI:99457 | Organism | mouse, laboratory |
| Chromosome | 18 | NCBI Gene Number | 17202 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables melanocyte-stimulating hormone receptor activity. Involved in positive regulation of bone resorption; regulation of eating behavior; and response to melanocyte-stimulating hormone. Acts upstream of or within several processes, including insulin secretion; response to food; and response to insulin. Predicted to be active in cytoplasm and plasma membrane. Is expressed in several structures, including axial skeleton; nervous system; and thyroid gland. Used to study metabolic dysfunction-associated steatohepatitis; obesity; and steatotic liver disease. Human ortholog(s) of this gene implicated in morbid obesity and obesity. Orthologous to human MC4R (melanocortin 4 receptor). PHENOTYPE: Mutations in this gene result in hyperglycemia and weight gain. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
