| Primary Identifier | MGI:1270845 | Organism | mouse, laboratory |
| Chromosome | 18 | NCBI Gene Number | 12683 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables lipid transfer activity; phosphatidic acid binding activity; and protein homodimerization activity. Involved in several processes, including lipid droplet fusion; negative regulation of cold-induced thermogenesis; and regulation of catabolic process. Acts upstream of or within lipid metabolic process. Located in mitochondrial envelope and nucleus. Colocalizes with lipid droplet. Is expressed in brown fat and inner ear vestibular component. Human ortholog(s) of this gene implicated in obesity. Orthologous to human CIDEA (cell death inducing DFFA like effector a). PHENOTYPE: Nullizygous mice show higher metabolic rate, lipolysis in BAT and core body temperature when subjected to cold treatment. They are lean and resistant to diet-induced obesity. Aging homozygotes exhibit dry eyes and hair, reduced sebaceous lipid secretion, hair loss, and poor water repulsion. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
