| Primary Identifier | MGI:97806 | Organism | mouse, laboratory |
| Chromosome | 18 | NCBI Gene Number | 19255 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables STAT family protein binding activity and protein tyrosine phosphatase activity. Involved in several processes, including hemopoiesis; negative regulation of leukocyte differentiation; and regulation of signal transduction. Acts upstream of or within insulin receptor signaling pathway; negative regulation of transcription by RNA polymerase II; and protein dephosphorylation. Located in nucleus. Is active in endosome lumen. Is expressed in several structures, including genitourinary system; heart; hemolymphoid system gland; lower jaw; and midbrain. Orthologous to human PTPN2 (protein tyrosine phosphatase non-receptor type 2). PHENOTYPE: Mice homozygous for disruptions in this gene have a reduced life span, abnormalities of the hematopoietic system and an increased succeptibility to inflammatory disease. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
