Primary Identifier | MGI:2652843 | Organism | mouse, laboratory |
Chromosome | 18 | NCBI Gene Number | 240396 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable RNA binding activity and ubiquitin protein ligase activity. Acts upstream of or within chondrocyte hypertrophy; energy homeostasis; and regulation of fat cell differentiation. Predicted to be located in cytoplasm and nucleus. Is expressed in several structures, including central nervous system and genitourinary system. Orthologous to human MEX3C (mex-3 RNA binding family member C). PHENOTYPE: Mice homozgyous for a gene trap allele exhibit strain dependent neonatal lethality and alveolar defects, growth retardation, and defects in long bone growth plate. Mice homozygous for a null allele display growth retardation and impaired cytokine production. [provided by MGI curators] |