Primary Identifier | MGI:2179288 | Organism | mouse, laboratory |
Chromosome | 18 | NCBI Gene Number | 246102 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Acts upstream of or within determination of left/right symmetry. Predicted to be located in centrosome and membrane. Predicted to be active in centriole and ciliary basal body. Is expressed in several structures, including branchial arch; embryo mesoderm; extraembryonic component; forelimb bud; and neural ectoderm. Orthologous to human RTTN (rotatin). PHENOTYPE: Mice homozygous for an insertional mutation exhibit embryonic lethality and neurulation defects resulting in the arrest of gastrulation movements and abnormal left-right specification in the heart. [provided by MGI curators] |