Primary Identifier | MGI:97811 | Organism | mouse, laboratory |
Chromosome | 19 | NCBI Gene Number | 19265 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to be active in plasma membrane. Is expressed in bone marrow; embryo; spleen; thymus; and thymus primordium. Orthologous to human PTPRCAP (protein tyrosine phosphatase receptor type C associated protein). PHENOTYPE: Mice homozygous for a knock-out allele display impaired T and B cell responses to antigen receptor stimulation. Mice for a second knock-out allele show enlarged lymph nodes and increased lymph node cellularity but not significantly altered polyclonal T-cell responses. [provided by MGI curators] |