| Primary Identifier | MGI:1328356 | Organism | mouse, laboratory |
| Chromosome | 19 | NCBI Gene Number | 19367 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable 3'-5' exonuclease activity; SH3 domain binding activity; and enzyme binding activity. Acts upstream of or within mitotic intra-S DNA damage checkpoint signaling and positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage. Located in cytoplasm and nucleus. Is expressed in male reproductive gland or organ; retina; telencephalon; and thyroid gland. Orthologous to human RAD9A (RAD9 checkpoint clamp component A). PHENOTYPE: Embryos homozygous for a knock-out allele are consistently smaller and display abnormal embryonic development and midgestational lethality associated with increased apoptosis and reduced cellular proliferation. Mutant mouse embryonic fibroblasts are not viable. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
