Primary Identifier | MGI:1916995 | Organism | mouse, laboratory |
Chromosome | 19 | NCBI Gene Number | 69745 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to contribute to DNA-directed DNA polymerase activity. Acts upstream of or within positive regulation of endothelial cell proliferation. Located in nucleus. Is expressed in several structures, including alimentary system; cranium; genitourinary system; liver; and respiratory system. Orthologous to human POLD4 (DNA polymerase delta 4, accessory subunit). PHENOTYPE: Mice homozygous for a null allele exhibit increased lifespan and decreased incidence of liver tumors. Another null allele shows decreased leukocyte numbers and decreased circulating glucose and calcium levels. [provided by MGI curators] |