| Primary Identifier | MGI:2685806 | Organism | mouse, laboratory |
| Chromosome | 19 | NCBI Gene Number | 381196 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity. Involved in meiotic DNA double-strand break formation and reciprocal meiotic recombination. Predicted to be located in chromosome. Is expressed in ovary; primary oocyte; secondary oocyte; and testis. Human ortholog(s) of this gene implicated in gestational trophoblastic neoplasm. Orthologous to human TOP6BL (TOP6B like initiator of meiotic double strand breaks). PHENOTYPE: Mice homozygous for a knock-out allele exhibit impaired double-strand break formation that imapires female and male meiosis and results in no spermatids and reduced primary and primordial follicle numbers. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
