Primary Identifier | MGI:1924963 | Organism | mouse, laboratory |
Chromosome | 19 | NCBI Gene Number | 240518 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables ubiquitin protein ligase activity. Acts upstream of or within several processes, including negative regulation of macromolecule metabolic process; protein K63-linked ubiquitination; and regulation of signal transduction. Is expressed in eye; ileum; male reproductive gland or organ; and nervous system. Orthologous to human PELI3 (pellino E3 ubiquitin protein ligase family member 3). PHENOTYPE: Mice homozygous for a null mutation display decreased susceptibility to viral infection. [provided by MGI curators] |