Primary Identifier | MGI:2664186 | Organism | mouse, laboratory |
Chromosome | 19 | NCBI Gene Number | 225872 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and protein heterodimerization activity. Involved in several processes, including chemical postsynaptic transmission; learning or memory; and modulation of chemical synaptic transmission. Acts upstream of or within cellular response to corticosterone stimulus and positive regulation of transcription by RNA polymerase II. Located in nucleus. Part of transcription regulator complex. Is expressed in several structures, including central nervous system; future forebrain; and urinary system. Orthologous to human NPAS4 (neuronal PAS domain protein 4). PHENOTYPE: Mice homozygous for a null allele exhibit hyperactivity, seizures and premature death. [provided by MGI curators] |