| Primary Identifier | MGI:101757 | Organism | mouse, laboratory |
| Chromosome | 19 | NCBI Gene Number | 12631 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables actin filament binding activity and signaling receptor binding activity. Involved in cytoskeleton organization; positive regulation of actin filament depolymerization; and positive regulation of embryonic development. Acts upstream of or within several processes, including neural crest cell migration; neural fold formation; and protein phosphorylation. Located in cell-cell junction; cortical actin cytoskeleton; and lamellipodium. Is active in glutamatergic synapse and postsynaptic density, intracellular component. Is expressed in several structures, including early conceptus; genitourinary system; immune system; nervous system; and skin. Orthologous to human CFL1 (cofilin 1). PHENOTYPE: Homozygous null mice display embryonic lethality with impaired neural crest cell migration, an open neural tube, and abnormal somite and eye development. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
