| Primary Identifier | MGI:1859821 | Organism | mouse, laboratory |
| Chromosome | 19 | NCBI Gene Number | 54683 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables thioredoxin-dependent peroxiredoxin activity. Predicted to be involved in several processes, including NADPH oxidation; cell redox homeostasis; and regulation of apoptotic process. Located in mitochondrion. Is expressed in several structures, including central nervous system; genitourinary system; retina; salivary gland; and spleen. Orthologous to human PRDX5 (peroxiredoxin 5). PHENOTYPE: Mice homozygous for a null allele show increased susceptibility to high fat diet-induced obesity and hepatic steatosis. Mice homozygous for a different null allele show elevated nitric oxide production and oxidative stress in bone-marrow-derived dendritic cells. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
