| Primary Identifier | MGI:1096330 | Organism | mouse, laboratory |
| Chromosome | 19 | NCBI Gene Number | 12015 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables cysteine-type endopeptidase activator activity involved in apoptotic process and protein phosphatase binding activity. Involved in several processes, including positive regulation of cell communication; positive regulation of mitochondrial membrane potential; and purine ribonucleotide metabolic process. Acts upstream of or within several processes, including apoptotic signaling pathway; positive regulation of lymphocyte differentiation; and symbiont-mediated activation of host apoptosis. Located in cytosol and mitochondrion. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and limb segment. Human ortholog(s) of this gene implicated in endometrial cancer; lung non-small cell carcinoma; and pancreatic cancer. Orthologous to human BAD (BCL2 associated agonist of cell death). PHENOTYPE: Mice homozygous for disruptions in this gene are grossly normal and fertile. Both T and B cells show increased sensitivity to gamma irradiation. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
