Primary Identifier | MGI:2147611 | Organism | mouse, laboratory |
Chromosome | 19 | NCBI Gene Number | 68229 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Involved in negative regulation of DNA-templated transcription. Predicted to be active in nucleus and site of DNA damage. Orthologous to human SPINDOC (spindlin interactor and repressor of chromatin binding). PHENOTYPE: Mice homozygous for null mutations of this gene are viable but exhibit decreased body weight, reduced levels of PARylation, and increased sensitivity to ionizing radiation. [provided by MGI curators] |